Gene expression, defence molecules and host-pathogen interactions in bivalve molluscs

Paola Venier, Umberto Rosani, Stefania Domeneghetti


The study of bivalve transcriptomes and available mollusc genomes currently provides molecular data supporting the general understanding of vital processes (i.e., host response to various stress factors) and the identification of markers for the experimental selection of vigorous stocks in coastal bivalve farming. At present, the research work reflect our interest in gene-encoded molecules acting in the innate immunity of economically relevant marine bivalves (receptors, signalling intermediates and effectors included cytokines), dual host-pathogen interactions and holobiomes, and disease-preventive strategies for a sustainable and innovative farming of bivalve and fish spp. To this purpose, peptides from Mytilus galloprovincialis, with or without antimicrobial activity, are under study.

Selected publications

Gerdol M., Venier P., 2015. An updated molecular basis for mussel immunity. Fish Shellfish Immunol. 46(1): 17-38.

Rosani U., Varotto L., Domeneghetti S., Arcangeli G., Pallavicini A., Venier P., 2014. Dual analysis of host and pathogen transcriptomes in ostreid herpesvirus 1-positive Crassostrea gigas. Environ Microbiol. doi: 10.1111/1462-2920.12706. [Epub ahead of print]

Domeneghetti S., Varotto L., Civettini M., Rosani U., Stauder M., Pretto T., Pezzati E., Arcangeli G., Turolla E., Pallavicini A., Venier P., 2014. Mortality occurrence and pathogen detection in Crassostrea gigas and Mytilus galloprovincialis close-growing in shallow waters (Goro lagoon, Italy). Fish Shellfish Immunol 41(1): 37-44.

Vezzulli L., Pezzati E., Stauder M., Stagnaro L., Venier P., Pruzzo C., 2015. Aquatic ecology of the oyster pathogens Vibrio splendidus and Vibrio aestuarianus. Environ Microbiol. 17(4): 1065-80.

Gerdol M., Puillandre N., Moro G.D., Guarnaccia C., Lucafò M., Benincasa M., Zlatev V., Manfrin C., Torboli V., Giulianini P.G., Sava G., Venier P., Pallavicini A., 2015. Identification and Characterization of a Novel Family of Cysteine-Rich Peptides (MgCRP-I) from Mytilus galloprovincialis. Genome Biol Evol. 7(8): 2203-19.